Obesity can increase risk of kidney failure
A new study has revealed that those who are classed as obese could be more at risk from kidney failure.
According to zeenews.india.com, researchers from Shiga University of Medical Science in Japan discovered that obesity can suppress a process called autophagy. This process helps to remove damaged proteins and other defective cell parts.
The researchers studied mice and found that autophagy functioned well in normal weight mice with kidney disease but obese mice with kidney disease suffered from suppressed autophagy and experienced kidney cell damage as a result.
In addition, mTOR (Mammalian target of rapamycin), which is a powerful suppressor of autophagy, is particularly active in the kidney's of obese mice. So increased mTOR could also affect the likelihood of kidney failure in obese patients.
Damaged kidney cells could lead to kidney failure and the research shows that the autophagy process could be the reason why obese patients are more at risk of kidney failure.
Kosuke Yamahara, one of the study's authors, said the study could help create a future treatment.
"Obesity suppresses autophagy via an abnormal activation of nutrition sensing signals in the kidney," he said. "Our results suggest that restoring the kidney-protective action of autophagy may improve the kidney health of obese patients," reports news-medical.net.